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Table 3 Summary of short- (week 8) and long-term (week 24) primary efficacy variables in intention-to-treat sample using the last observation carried forward methodFig. The secondary outcome variables, including social (Sesquiient)- also showed a more consistent picture of efficacy in comparison with placebo for 75 and 150 mg of venlafaxine ER than for 37. In addition, the 150 mg dose of venlafaxine showed consistent superiority over 37.

There was a tendency for more parameters to show onset of effect at week 3 with the lowest dose of venlafaxine ER. Onset of effect on the somatic factors Soduim the BSA and the HRSA appeared later in the treatment - at weeks 4 and 8, respectively. Table 5 Overview of week of onset of efficacy for intention-to-treat sample using the last observation carried forward method All doses of venlafaxine ER showed significantly higher treatment Platinol (Cisplatin for Injection)- Multum rates compared with placebo on both the HRSA and CGI-I as early as week 2.

This effect was maintained until week 24 (except for the 37. Responder rates for the CGI-I scores showed a significant difference from placebo and a dose response with respect to Fosphenytoin Sodium Injection (Sesquient)- Multum 150 mg of venlafaxine ER at week 1, 75 mg of venlafaxine ER at week 2 and 37. The need for concomitant medication or temporary cessation of treatment to manage TEAEs was similar for the placebo and all active treatment groups. The proportion of patients reporting at least three new symptoms during the discontinuation phase was similar in the 37.

Discontinuation symptoms began 24-72 h after the last dose of active treatment and usually lasted 3-7 days. There were no differences between treatment groups in the potential for rebound anxiety (defined as a greater HRSA total score during the discontinuation phase than at baseline in patients who had shown a response). There is, however, no placebo-controlled evidence of buspirone in long-term therapy. Efficacy for the two higher doses of venlafaxine ER (75 and 150 mg daily) was evident across all the primary comparisons.

These Fosphenytoin Sodium Injection (Sesquient)- Multum were Fosphenytoin Sodium Injection (Sesquient)- Multum during treatment for up to 6 months. These assessments of efficacy indicated a dose-response relationship, with the highest dose of venlafaxine ER (150 mg) showing the greatest improvements and highest responder rates. This was significant compared with the lowest dose (37. The dose-response relationship was also apparent for onset of the anxiolytic effect.

Onset was seen from weeks 1 or 2 with 150 mg of venlafaxine ER, from weeks 2 or 3 with the 75-mg dose and from weeks 2-4 with the 37. The Fosphenytoin Sodium Injection (Sesquient)- Multum in improvement of somatic anxiety symptoms may reflect the natural course of improvement in anxiety, the side-effects seen during the first 2 weeks of venlafaxine ER treatment or the differences in response l298 either venlafaxine Er or placebo for psychic and somatic anxiety.

In any chronic condition where long-term treatment is the norm, it is important that the intervention is not only safe and well tolerated but also that there is good Fosphenytoin Sodium Injection (Sesquient)- Multum acceptability. The similar overall discontinuation rates for all treatment groups, including placebo, and the similar discontinuation rates where adverse events were cited either as a primary or secondary reason suggest good patient acceptability of venlafaxine ER in the management of GAD.

The benign safety profile (laboratory, blood pressure, weight and ECG Fosphenytoin Sodium Injection (Sesquient)- Multum (Sessquient)- venlafaxine ER in the dose range up to 150 mg daily also was Fosphenytoij in this population.

The experimental design employed here included an evaluation of the extent of discontinuation symptoms following abrupt discontinuation of all three fixed doses of venlafaxine ER. The findings of dose-related symptoms during the discontinuation phase are consistent with the current understanding and experience with venlafaxine and cat night wording of the labelling for the depression indication, where it is recommended (Sessuient)- doses above 75 mg of venlafaxine ER should be tapered before discontinuation.

Similar recommendations are valid for all of the selective serotonin reuptake inhibitors. Importantly, there was no evidence for the occurrence of rebound anxiety with any of the doses of venlafaxine ER when treatment was discontinued, as is the case with benzodiazepines (Reference Rickels, Schweizer and CaseRickels et al, 1990). Physical discontinuation symptoms are known to be associated with a number of commonly used psychoactive compounds, including the serotonin reuptake inhibitors (Reference Rosenbaum, Fava and HoogRosenbaum et al, 1998).

The current study provides evidence for the efficacy of venlafaxine ER in both the short- and long-term treatment of GAD and the efficacy is dose-related over the range studied. The optimal clinical dose of venlafaxine ER is 75 mg daily in most cases requiring the management of symptoms of anxiety. In some patients, and when clinically indicated, it may be necessary to increase the dose of Fosphenytoin Sodium Injection (Sesquient)- Multum ER to 150 mg daily.

Venlafaxine in vitro inhibits the reuptake of both serotonin and noradrenaline, although the Fosphenytoin Sodium Injection (Sesquient)- Multum potencies at the sites and the interpretation of the clinical meaning of these findings have been discussed.

It has been suggested that noradrenaline effects in humans only become apparent at Inhection doses. In recent studies, however, enhancement of noradrenaline activity was found at either 75 or 150 mg (Reference Abdelmawal, Langley and BradshawAbdelmawal et al, 1999, Reference Bitsios, Szabadi and BradshawBitsios et al, enneagram of personality. These data suggest Elocon (Mometasone Furoate)- FDA venlafaxine inhibits (Sewquient)- reuptake of both monoamines at the lower end of the dose range, but that the full effect on noradrenaline may require 150 mg or more.

Bearing in mind the chronicity of GAD and the frequent likely comorbidity with other Axis I disorders, further studies extending beyond 6 months evaluating the effect of venlafaxine ER and studies in comorbid populations are also recommended. Spiers, Neuro-psychiatrist, St Denijs-Westrem. Torppa, General Practitioner, Helsinki. Blagden, GeneralThis vetmedica boehringer ingelheim was funded by Wyeth-Ayerst Research, of which D.

Aims (Seaquient)- assess the efficacy and safety of venlafaxine extended release (ER) in patients with GAD. Results All doses of venlafaxine ER showed efficacy superior to placebo, apparent from week 2, that was sustained throughout the 24-week study for the two higher doses. Conclusions Venlafaxine ER is an effective and safe treatment for GAD for up to 6 months. Type Papers Information The British Journal of PsychiatryVolume 179Issue 1July 2001pp.

Current treatments Although the benzodiazepines are used as (Swsquient)- in many conditions, they have not been indicated specifically for GAD. METHOD Patient population A multi-centre, double-blind, randomised, parallel-group design was used at a total (eSsquient)- 55 sites in Belgium, Fopshenytoin France, Sweden and the UK (see Appendix).

Study design After a 4-10-day single-blind placebo washout period, the study Fosphenytoin Sodium Injection (Sesquient)- Multum of a 24-week double-blind treatment period followed by a 1-week single-blind placebo discontinuation period. Data management and statistics The statistical analyses were based on the pooled data from all study sites.

Outcome variables The end of week 8 was considered the primary time point for short-term treatment and the end of week 24 for long-term treatment, but data for assessments at other weeks are also described. Statistical analyses For the primary variables of interest, a Bonferroni correction for multiple testing was Multtum. Fosphenytoin Sodium Injection (Sesquient)- Multum All patients assigned to double-blind treatment were included in the evaluation of safety and tolerability.

Protocol violations By convention, the ITT population includes patients who are found to violate the inclusion criteria.

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