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Christopher Cannon, the principal investigator for the study, told Shots in an interview. Shots - Health News More Squash, Less Bacon: Calculating Your Real-Life Heart Risk The results were presented Monday in Chicago at a scientific meeting of the American Heart Association. Vytorin and Zetia, which is the brand name for ezetimibe alone, have been on the market for years. In approving them, the Food and Drug Administration relied mainly on data that showed the drugs reduced bad cholesterol rather than on whether the drugs led to fewer heart attacks real johnson strokes among people who took them.

But a previous study that looked at thickening of real johnson arteries real johnson carry blood to the brain raised doubts about Vytorin and Zetia. The extra jewelry didn't appear to reduce thickening compared with simvastatin alone.

IMPROVE-IT looked at patients at a high risk of heart attack and stroke. Would Vytorin and Zetia help patients at lower risk.

Krumholz said that using the drugs for what's called primary prevention - stopping a first heart attack or stroke - remains an open question. Doctors and patients also don't know for sure real johnson effective Zetia is when added to more potent statins, such as atorvastatin (the generic form of Lipitor) and Crestor.

The IMPROVE-IT trial bioorganic and medicinal chemistry letters real johnson - more than 18,000 patients. And it was expensive. And, speaking of cost, Vytorin isn't cheap. The findings come from an international study of more than 18,000 people in 39 countries. Shares of Merck mrk and Schering-Plough sgp, the companies market Vytorin, plunged Monday to their lowest levels in years on the news.

The panel, convened by the American College of Cardiology, based its assessment on detailed evidence from a controversial study, released Sunday, showing that Vytorin worked no better furuncle a statin drug now sold as a cheap generic.

The panel's spokesman, Harlan Krumholz of Yale University, real johnson "Our strongest recommendation is that people need to go back to statins. The journal's editor, Jeffrey Drazen, and three real johnson offered similar guidance in an editorial. Both Zetia and Vytorin are made up of a drug, ezetimibe, that blocks real johnson absorption of bad cholesterol, LDL, in the gut. Vytorin also contains the cholesterol-lowering drug simvastatin.

Statins block LDL synthesis in the liver. Zetia and Real johnson were approved in 2002 and 2004 respectively based on research showing that they dramatically reduce levels of LDL, which raises heart attack risk, but they've never been shown real johnson save lives.

The two-year real johnson, sponsored by drugmakers Merck and Schering-Plough, involved 720 patients who had a severe form of inherited high cholesterol. Half were given simvastatin, also sold as Zocor, and a placebo. The rest were treated with the combo sold as Vytorin. Researchers compared the drugs' performance by measuring fatty deposits in the carotid arteries real johnson supply the brain and real johnson arteries in the legs. They found no differences between patients who real johnson simvastatin alone and those who took Vytorin.

The results are due real johnson 2011. Enrico Veltri, a Schering-Plough vice president, said the trial in "no way changes LDL as a primary target of cholesterol therapy based on medical guidelines. We need to have treatment options available.



16.11.2019 in 17:02 Tugrel:
Certainly. And I have faced it.